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Lymphoma of the Blood and Lymph system


Lymphoma of the Blood and Lymph system

Lymphoma is a type of cancer that affects the lymphatic system, which is a network of vessels and organs that help to protect the body from infection and disease. 

In lymphoma of the blood and lymph system, cancer cells develop in the lymphatic system and can spread throughout the body. This can cause enlargement of the lymph nodes, spleen, and other organs, as well as symptoms such as fever, night sweats, weight loss, and fatigue.

Types of Lymphoma of the Blood and Lymph System

There are two main types of lymphoma – Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL). Both types of lymphoma can affect the blood and lymph system.

  1. Hodgkin lymphoma – HL is a type of lymphoma that is characterized by the presence of a specific type of abnormal cell called the Reed-Sternberg cell. HL usually starts in a single lymph node and then spreads to nearby lymph nodes. HL can also spread to other organs, including the bone marrow, liver, and lungs. There are two main types of HL – Classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma.
  2. Non-Hodgkin lymphoma – NHL is a type of lymphoma that originates in the lymphocytes, which are a type of white blood cell. NHL can start in any part of the body, including the lymph nodes, bone marrow, spleen, and other organs. There are many subtypes of NHL, which can be classified based on the type of cell that is affected, the location of the cancer, and other factors.

Lymphoma of the Blood and Lymph system

Causes and Risk Factors

The causes of lymphoma in the blood and lymph system are not well understood. However, research has identified some risk factors that may increase a person’s likelihood of developing this type of cancer. Some of these risk factors include –

  1. Age – Lymphoma is more common in older adults, with most cases occurring in people over the age of 60.
  2. Gender – Some types of lymphoma are more common in men than in women.
  3. Family history – People who have a family history of lymphoma or other types of cancer may have a higher risk of developing lymphoma.
  4. Immune system disorders – Certain autoimmune diseases, such as rheumatoid arthritis and lupus, can increase the risk of lymphoma.
  5. Infections – Certain viral and bacterial infections, such as the Epstein-Barr virus and the Helicobacter pylori bacteria, have been linked to an increased risk of lymphoma.
  6. Exposure to certain chemicals – Exposure to certain chemicals, such as pesticides and herbicides, may increase the risk of lymphoma.
  7. Radiation exposure – Exposure to high levels of radiation, such as during radiation therapy for cancer, can increase the risk of lymphoma.

Having one or more of these risk factors does not necessarily mean that a person will develop lymphoma, and many people with lymphoma do not have any known risk factors. Regular check-ups with a healthcare provider and maintaining a healthy lifestyle can help to reduce the risk of developing lymphoma.


The symptoms of lymphoma of the blood and lymph system can vary depending on the type and stage of cancer, as well as the location of the affected lymph nodes or organs. Some common symptoms of lymphoma may include –

  1. Swollen lymph nodes – The most common symptom of lymphoma is swollen lymph nodes, which can be painless or tender to the touch. The swelling may occur in the neck, armpits, groin, or other areas of the body.
  2. Fatigue – Many people with lymphoma experience fatigue or weakness, which can be caused by the cancer itself or by the body’s immune response to the cancer.
  3. Fever – A fever may be a sign of infection or inflammation, which can be caused by lymphoma.
  4. Night sweats –  Many people with lymphoma experience night sweats, which can be severe enough to soak through clothing or bedding.
  5. Unexplained weight loss – Unexplained weight loss of 10% or more of body weight can be a sign of lymphoma.
  6. Itchy skin – Some people with lymphoma may experience itchy skin or a rash, which can be caused by the immune response to the cancer.
  7. Pain – Lymphoma can sometimes cause pain or discomfort, especially if it affects the bone marrow or other organs.

These symptoms can be caused by many other conditions besides lymphoma. However, if you are experiencing any of these symptoms, especially if they are persistent or worsening over time, it is important to see a healthcare provider for evaluation and diagnosis.

Diagnosis and Tests

The diagnosis of lymphoma of the blood and lymph system usually involves a combination of tests and procedures, including –

  1. Physical examination – A healthcare provider will examine the body for any signs of lymphoma, such as swollen lymph nodes, and will ask about symptoms and medical history.
  2. Blood tests – Blood tests can help detect abnormalities in the blood cells and other markers that may indicate lymphoma.
  3. Imaging tests – Imaging tests, such as X-rays, computed tomography (CT) scans, magnetic resonance imaging (MRI) scans, and positron emission tomography (PET) scans, can help visualize the lymph nodes and other organs to look for signs of cancer.
  4. Biopsy – A biopsy involves removing a small sample of tissue from a lymph node or other affected area for examination under a microscope to look for cancer cells. Depending on the location of the lymphoma, different biopsy techniques may be used, such as fine needle aspiration, core needle biopsy, or surgical biopsy.
  5. Bone marrow biopsy – A bone marrow biopsy involves taking a sample of bone marrow from the hip bone to check for the presence of lymphoma cells.
  6. Lymph node biopsy – A lymph node biopsy involves removing one or more lymph nodes for examination under a microscope.

If the diagnosis is confirmed, further tests may be needed to determine the stage and extent of the lymphoma, which will help guide treatment decisions. These may include additional imaging tests, such as a PET-CT scan, and other tests to assess the function of different organs in the body.


The treatment of lymphoma of the blood and lymph system depends on several factors, including the type and stage of cancer, the location and extent of the disease, and the person’s overall health and preferences. Treatment options may include –

  1. Chemotherapy – Chemotherapy involves using drugs to kill cancer cells. It is often the main treatment for lymphoma, especially aggressive types, or when the disease has spread to many parts of the body.
  2. Radiation therapy – Radiation therapy involves using high-energy radiation to kill cancer cells. It may be used alone or in combination with chemotherapy, depending on the stage and location of the lymphoma.
  3. Immunotherapy – Immunotherapy involves using drugs to stimulate the immune system to recognize and attack cancer cells. It is often used in combination with chemotherapy, especially for certain types of lymphoma.
  4. Stem cell transplant – A stem cell transplant involves replacing the body’s blood-forming cells with healthy stem cells, usually from a donor, to help the body produce new, healthy blood cells. It may be used as a treatment for some types of lymphoma, especially if the disease has relapsed or is resistant to other treatments.
  5. Surgery – Surgery is rarely used to treat lymphoma, but may be needed in certain cases, such as to remove a large mass or to obtain a tissue sample for diagnosis.

The choice of treatment depends on several factors, including the type and stage of the lymphoma, the person’s overall health, and personal preferences. It is important to discuss treatment options and potential side effects with a healthcare provider to make an informed decision about the best approach for the individual situation.


The outlook, or prognosis, for lymphoma of the blood and lymph system, varies depending on several factors, including the type and stage of cancer, the age and overall health of the person, and how well the cancer responds to treatment. In general, lymphoma is a treatable cancer, and many people with lymphoma can be cured or achieve long-term remission with appropriate treatment.

Every person’s experience with lymphoma is unique, and prognosis and treatment outcomes can vary widely. It is important to work closely with a healthcare provider to develop an individualized treatment plan and to seek support from family, friends, and healthcare professionals throughout the cancer journey.

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